Background: Bleeding after percutaneous coronary interventions (PCI) is an important complication with impact on prognosis. Aim: To evaluate the predictive value of enhanced platelet responsiveness to dual antiplatelet therapy with aspirin and clopidogrel, for bleeding, after elective PCI. Method and results: We performed multiple electrode aggregometry (MAE) platelet functional tests induced by arachidonic acid (ASPI) and adenosine-diphosphate (ADP) before PCI, and 24 hours after PCI, in 481 elective PCI patients who were followed-up for an average of 15.34±7.19 months. Primary end point was the occurrence of any bleeding, while ischemic major adverse cardiovascular event (MACE) was a secondary endpoint. The incidence of total, BARC≤2, and BARC≥3 bleeding, according to BARC classification, was 19%, 18% and 1%, respectively.

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Groups with any, and BARC≤2 bleeding, had a lower average value of MAE ADP test after 24h, compared to the group without bleeding: 45.30±18.63 U vs. 50.99±19.01 U; p=0.005.